Association analysis of whole genome sequencing data accounting for longitudinal and family designs.

TitleAssociation analysis of whole genome sequencing data accounting for longitudinal and family designs.
Publication TypeJournal Article
Year of Publication2014
AuthorsHu, Y., Hui Q., & Sun Y. V.
JournalBMC Proc
Volume8
IssueSuppl 1 Genetic Analysis Workshop 18Vanessa Olmo
PaginationS89
Date Published2014
ISSN1753-6561
Abstract

Using the whole genome sequencing data and the simulated longitudinal phenotypes for 849 pedigree-based individuals from Genetic Analysis Workshop 18, we investigated various approaches to detecting the association of rare and common variants with blood pressure traits. We compared three strategies for longitudinal data: (a) using the baseline measurement only, (b) using the average from multiple visits, and (c) using all individual measurements. We also compared the power of using all of the pedigree-based data and the unrelated subset. The analyses were performed without knowledge of the underlying simulating model.

DOI10.1186/1753-6561-8-S1-S89
Alternate JournalBMC Proc
PubMed ID25519416
PubMed Central IDPMC4143808