A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.

TitleA Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.
Publication TypeJournal Article
Year of Publication2016
AuthorsTaylor, J. Y., Schwander K., Kardia S. L. R., Arnett D., Liang J., Hunt S. C., Rao D. C., & Sun Y. V.
JournalSci Rep
Volume6
Pagination18812
Date Published2016
ISSN2045-2322
Abstract

Cigarette smoking has been shown to be a health hazard. In addition to being considered a negative lifestyle behavior, studies have shown that cigarette smoking has been linked to genetic underpinnings of hypertension. Because African Americans have the highest incidence and prevalence of hypertension, we examined the joint effect of genetics and cigarette smoking on health among this understudied population. The sample included African Americans from the genome wide association studies of HyperGEN (N = 1083, discovery sample) and GENOA (N = 1427, replication sample), both part of the FBPP. Results suggested that 2 SNPs located on chromosomes 14 (NEDD8; rs11158609; raw p = 9.80 × 10(-9), genomic control-adjusted p = 2.09 × 10(-7)) and 17 (TTYH2; rs8078051; raw p = 6.28 × 10(-8), genomic control-adjusted p = 9.65 × 10(-7)) were associated with SBP including the genetic interaction with cigarette smoking. These two SNPs were not associated with SBP in a main genetic effect only model. This study advances knowledge in the area of main and joint effects of genetics and cigarette smoking on hypertension among African Americans and offers a model to the reader for assessing these risks. More research is required to determine how these genes play a role in expression of hypertension.

DOI10.1038/srep18812
Alternate JournalSci Rep
PubMed ID26752167
PubMed Central IDPMC4707536
Grant List2 R01 HL55673-12 / HL / NHLBI NIH HHS / United States
HL100185 / HL / NHLBI NIH HHS / United States
HL54471 / HL / NHLBI NIH HHS / United States
HL54472 / HL / NHLBI NIH HHS / United States
HL54473 / HL / NHLBI NIH HHS / United States
HL54495 / HL / NHLBI NIH HHS / United States
HL54496 / HL / NHLBI NIH HHS / United States
HL54497 / HL / NHLBI NIH HHS / United States
HL54509 / HL / NHLBI NIH HHS / United States
HL54515 / HL / NHLBI NIH HHS / United States
R01 HL107552 / HL / NHLBI NIH HHS / United States
U01 HL054471 / HL / NHLBI NIH HHS / United States